AI · Studies · 2026-09-09 12:13:00
Cornell researchers used AI to uncover a previously unknown way cells control how proteins move inside them, a process often disrupted in cancer. Published September 9 in the Journal of Cell Biology, the study shows the little-understood protein Avl9 acts as an "off switch" for Arf1, which directs where materials go inside cells. Using AlphaFold, the team identified Avl9 as a previously unknown partner of Arf1. Experiments confirmed Avl9 shuts down Arf1 after it performs its role. The researchers also found that some DENN domain proteins previously thought to be "on switches" instead act as "off switches."
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